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KMID : 0620920180500050058
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Experimental & Molecular Medicine
2018 Volume.50 No. 5 p.58 ~ p.58
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Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma
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Choi Gil-Soon
Trinh Hoang Kim Tu
Yang Eun-Mi
Ye Young-Min
Shin Yoo-Seob
Kim Seung-Hyun
Park Hae-Sim
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Abstract
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Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs). Serum CLU and PGRN levels were significantly lower in the TDI-OA group than in the AEC and NC groups (P?
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KEYWORD
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Asthma, Diagnostic markers, Immunopathogenesis
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